Clostridium difficile Toxins and Severe C. difficile Infection
نویسندگان
چکیده
منابع مشابه
Clostridium difficile toxins and severe C. difficile infection.
The pathogenesis of colitis due to Clostridium difficile is closely linked to the elaboration of 2 large, single-unit glucosyltransferases referred to as toxin A (TcdA) and toxin B (TcdB). Clinical isolates from patients with symptomatic C. difficile infection (CDI) invariably produce both TcdA and TcdB or TcdB alone. Vaccination of experimental hamsters against both toxins prevents fatal C. di...
متن کاملToxins A and B of Clostridium difficile.
The toxins produced by Clostridium difficile share several functional properties with other bacterial toxins, like the heat-labile enterotoxin of Escherichia coli and cholera toxin. However, functional and structural differences also exist. Like cholera toxin, their main target is the disruption of the microfilaments in the cell. However, since these effects are not reversible, as found with ch...
متن کاملOverlapping roles for toxins in Clostridium difficile infection.
All bacterial infections are of great concern to society. Some bacterial infections, however, seem to have periods of high drama or wider public health import. The 100 or so known species of Clostridium (from the Greek kloster or “spindle”; phylum Firmicutes) belong to a group of obligately anaerobic, gram-positive, spore-forming, rod-shaped bacteria. Of these, only a handful are pathogenic to ...
متن کاملClostridium difficile Infection.
Clostridium difficile infection is a major health care challenge in terms of patient and economic consequences. For the patient, it is a morbid and sometimes a life-threatening iatrogenic complication of antibiotic treatment. In the United States, the provider's institution may face financial penalties, because the Centers for Disease Control and Prevention views this as an iatrogenic health ca...
متن کاملClostridium difficile infection
Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2014. This is an Open Access article distributed of terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided article is properly cited. Clostridium difficile infection (CDI) is a significant and increasing medical problem, surpassing m...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 2011
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jir752